Epic Astrobiology The study of life, its origins, forms, and possible presence beyond the Earth is experiencing a renaissance. Much of this is driven by discoveries here, on Mars and in our solar system, and especially in the abundant and diverse population of planets around other stars. I will review some of the more interesting pieces of science, and discuss the theoretical and observational challenges that are particular for astronomy, as well as ways in which we're making progress and what we can expect from this odyssey in the near future.