Measuring the most massive black holes in the Universe Dr. Shai Kaspi Tel-Aviv University & Technion, Israel It is now widely believed that supermassive black holes with masses of million to billion solar masses reside in the center of every galaxy. Such supermassive black holes are also responsible for the high luminosity and activity in active galactic nuclei (AGN). The mass of these black holes is an important parameter which has to be measured in order to characterize and understand the black hole phenomenon. In this talk I will review the method of "reverberation mapping" to measure the most supermassive black holes in the Universe. The talk will focus on the emerging relations between the broad-line region size, the AGN luminosity, and the supermassive black hole mass, and their broad implications. Also will be reviewed recent results of reverberation mapping studies which are starting to cover the full AGN luminosity range as well as future prospects of this field.